2H-1,5-Benzodiazepin-2-one, 1,3,4,5-tetrahydro-4-methyl-6-[1-methyl-3-(1-methyl-1H-pyrazol-4-yl)-1H-indazol-5-yl]-, (4R)-
CPI-637
CAS: 1884712-47-3
Molecular Formula: C22H22N6O
2H-1,5-Benzodiazepin-2-one, 1,3,4,5-tetrahydro-4-methyl-6-[1-methyl-3-(1-methyl-1H-pyrazol-4-yl)-1H-indazol-5-yl]-, (4R)- - Names and Identifiers
| Name | CPI-637 |
| Synonyms | CPI637 CPI 637 CPI-637 2H-1,5-Benzodiazepin-2-one, 1,3,4,5-tetrahydro-4-methyl-6-[1-methyl-3-(1-methyl-1H-pyrazol-4-yl)-1H-indazol-5-yl]-, (4R)- |
| CAS | 1884712-47-3 |
2H-1,5-Benzodiazepin-2-one, 1,3,4,5-tetrahydro-4-methyl-6-[1-methyl-3-(1-methyl-1H-pyrazol-4-yl)-1H-indazol-5-yl]-, (4R)- - Physico-chemical Properties
| Molecular Formula | C22H22N6O |
| Molar Mass | 386.45 |
| Density | 1.38±0.1 g/cm3(Predicted) |
| Boling Point | 689.2±55.0 °C(Predicted) |
| Solubility | DMSO |
| pKa | 14.62±0.40(Predicted) |
| Storage Condition | -20℃ |
| In vitro study | CPI-637 inhibited the expression of MYC in AMO-1 cells (EC50=0.6 μm). |
2H-1,5-Benzodiazepin-2-one, 1,3,4,5-tetrahydro-4-methyl-6-[1-methyl-3-(1-methyl-1H-pyrazol-4-yl)-1H-indazol-5-yl]-, (4R)- - Preparation solution concentration reference
| 1mg | 5mg | 10mg | |
|---|---|---|---|
| 1 mM | 2.588 ml | 12.938 ml | 25.877 ml |
| 5 mM | 0.518 ml | 2.588 ml | 5.175 ml |
| 10 mM | 0.259 ml | 1.294 ml | 2.588 ml |
| 5 mM | 0.052 ml | 0.259 ml | 0.518 ml |
Last Update：2024-01-02 23:10:35
2H-1,5-Benzodiazepin-2-one, 1,3,4,5-tetrahydro-4-methyl-6-[1-methyl-3-(1-methyl-1H-pyrazol-4-yl)-1H-indazol-5-yl]-, (4R)- - Reference Information
| biological activity | CPI-637 is a selective, cytoactive CBP/EP300 bromodomain protein inhibitor. In the TR-FRET assay, the IC50 for CBP and EP300 CPI-637 was 0.03 μm and 0.051 μm, respectively. In other bromine domain, it is highly selective, in contrast, the biochemical activity of BRD9 is more prominent. |
| Target | Value |
| CBP (Cell-free assay) | 0.03 μM |
| EP300 (Cell-free assay) | 0.051 μM |
Last Update：2024-04-09 21:54:55
![2H-1,5-Benzodiazepin-2-one, 1,3,4,5-tetrahydro-4-methyl-6-[1-methyl-3-(1-methyl-1H-pyrazol-4-yl)-1H-indazol-5-yl]-, (4R)-](http://res.chembk.com/assets/str/2d/1/18/1884712-47-3.png)
Supplier List
Spot supply
Product Name: CPI-637 Visit Supplier Webpage Request for quotationCAS: 1884712-47-3
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
Wechat: 18301782025
Spot supply
Product Name: CPI-637 Visit Supplier Webpage Request for quotationCAS: 1884712-47-3
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
Wechat: 18301782025
View History